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Nrf2 as a Therapeutic Target for Stroke and Neurodegeneration
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Stroke is a leading cause of death and disability in§North America. §One major cause of nerve tissue damage during stroke§is the §accumulation of reactive oxygen species- molecules§that steal §electrons from healthy cells in a process known as§oxidation. This §thesis describes a novel approach to increase§antioxidant levels in §order to maintain oxidative balance and prevent§cellular damage §during stroke. The stress-responsive transcription§factor, Nrf2, is §able to launch the endogenous mechanisms of cellular§defense and §repair. Nrf2 represents a master switch that§coordinates tens to §hundreds of antioxidant and detoxification genes§working in §synergy. In rodent models of stroke and§neurodegeneration, §increased Nrf2 activity was found to promote neuronal§survival and §improve recovery of limb function weeks to months§following injury. §Interestingly, a number of molecules that activate§Nrf2 are found in §cruciferous vegetables, such as broccoli sprouts,§suggesting the §possibility of practical diet-based therapies.
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