Urinary Incontinence

Urinary Incontinence: Integrating Science and Clinical Practice provides a succinct elaboration of the current understanding of the system function of lower urinary tract physiology. Through the combination of scientific knowledge by world-leading contributors and clinical relevance provided by the editorial team, comprehensive coverage of the key influences on mechanisms and therapies within urinary incontinence are presented for proper understanding of the scientific basis of incontinence and its clinical treatment. The book is presented in two parts; the first is dedicated to System Physiology: Function and Adaptation. In this section an anatomical sequence will be followed for presenting the chapters, moving from the lower urinary tract organs upwards through the spinal centers to the brain, revealing what is known and what is not known. The second is dedicated to Incontinence: Mechanism and Therapy. In this clinical application section, the chapters will be derived from the clinical classification of incontinence, incorporating some of the major unanswered questions, such as; what urodynamics can tell us about the passive physical and contractile properties of the bladder; how neuromodulation works; the sensations arising from the LUT; how the physical properties of the outflow tract are obtained from urethral pressure profiles; how PET and fMRI images are interpreted and what principles of drug design and outcome measures are validated as repeatable. The integrative systems approach to both science and clinical perspectives to further the study of urological pathophysiology makes this the perfect reference for both clinicians who would like to know more about the scientific basis of their clinical subjects and laboratory scientists wanting to know what the current clinical challenges of urinary incontinence are. Integration of scientific knowledge by world-leading contributors with clinical relevance from the editorial team for comprehensive coverage of the key influences on mechanisms and therapies within urinary incontinenceCoverage of important topics including flow dynamics, neuromodulation and sensations arising from LUT are combined with insight into how PET and fMRI images are interpreted in the incontinence context providing a comprehensive viewProvides insight into what urodynamics can tell us about the passive physical and contractile properties of the bladderInvestigates the principles of drug design and what outcomes can be validated as repeatable measures