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Tumor Therapy Monitoring with Diffuse Optical Spectroscopies
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The diffuse optical technique using Near-Infrared §(NIR) light provides a promising§means for non-invasive imaging and clinical §diagnosis of deep tissues. This book focuses on a §multi-modal diffuse optical technique combining two §qualitatively different methodologies: Diffuse §Reflectance Spectroscopy (DRS) and Diffuse §Correlation Spectroscopy (DCS). This approach §permits real-time, non-invasive and simultaneous §quantification of tissue hemoglobin concentration, §blood oxygen saturation and blood flow. This book §outlines the basic principles, mathematical modeling §and then practical instrumentation that enable §monitoring of tumor responses to therapies in §preclinical and clinical contexts. Targeted audience §of this book is scientists who are interested in §basic principles of diffuse optics and its §applications to translational research and medical §doctors who are interested in practical tools for §therapy monitoring in clinics.
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