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This book presents a series of perspectives on the therapeutic potential of the ritual and clinical use of the Amazonian hallucinogenic brew ayahuasca in the treatment and management of various diseases and ailments, especially its role in psychological well-being and substance dependence. Anthropological and biomedical data on the use of ayahuasca for treating depression, PTSD, and substance dependence in different settings, such as indigenous contexts, neo-shamanic rituals, contemporary therapeutic circles, and in ayahuasca religions, in both South and North America, are presented and critiqued.§The texts in this book also discuss methodological, ethical, and political considerations for current and future research in this area. The book aims to bring the therapeutic use of ayahuasca to a new level of public examination and academic debate, as well as to fill in gaps in the current literature. Though there are a number of anecdotal reports on the therapeutic use of ayahuasca, there has been no systematic and intensive work on the topic thus far.§