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The Collaborative Research Center SFB 401: Flow Modulation and Fluid-Structure§Interaction at Airplane Wings investigates numerically and experimentally fundamental§problems of very high capacity aircraft having large elastic wings. This issue summarizes§the findings of the 12-year research program at RWTH Aachen University which§was funded by the Deutsche Forschungsgemeinschaft (DFG) from 1997 through§2008. The research program covered the following three main topics of large transport§aircraft: (i) Model flow, wakes, and vortices of airplanes in high-lift-configuration,§(ii) Numerical tools for large scale adaptive flow simulation based on multiscale§analysis and a parametric mapping concept for grid generation, and (iii) Validated§computational design tools based on direct aeroelastic simulation with reduced§structural models.