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This represents the first work to cover the structural bioinformatics of membrane proteins. With a focus on membrane proteins from the perspective of bioinformatics, the present work covers a broad spectrum of topics in evolution, structure, function, and bioinformatics of membrane proteins focusing on the most recent experimental results. Leaders in the field who have recently reported breakthrough advances cover algorithms, databases and their applications to the subject. §The sufficient number of membrane protein structures beginning to emerge makes the expert coverage presented here very timely. §Structural bioinformatics of membrane proteins has been an active area of research over the last thee decades and proves to be a growing field of interest.