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This is the first book fully devoted to the implementation of statistical methods in imaging, optics, and photonics applications with a concentration on statistical inference. The text contains a wide range of relevant statistical methods, including a review of the fundamentals of statistics and expanding into multivariate techniques. The techniques are explained in the context of real examples from various disciplines. It serves as a reference for professionals working in imaging, optics, and photonics; as a textbook for advanced undergraduate and graduate-level courses in multivariate statistics for imaging science, optics, and photonics; and as a supplementary resource in any of the above mentioned courses.