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This text offers a thorough overview of the field of solid-phase organic synthesis. Coverage focuses on fundamentals of heterogeneous supports in the synthesis of organic molecules and explains the use of a solid material to support and thereby facilitate organic synthesis. Chapters are divided into two sections; the first introduces some general concepts and strategies, while the second presents specific examples of the solid-phase synthesis of various classes of organic molecules. Application examples include bioimaging probes and sensors, asymmetric synthesis, dendritic molecules, diversity oriented-synthesis, library design, and combinatorial chemistry.