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Role for PP1g2 in Spermatogenesis
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Targeted disruption of the Ppp1cc gene causes male§infertility in mice due to impaired spermiogenesis.§We observed that PP1g2 was prominently expressed in§cytoplasm of secondary spermatocytes and round§spermatids as well as in elongating spermatids and§testicular and epididymal spermatozoa, while its§expression was weak or absent in spermatogonia,§pachytene spermatocytes, and interstitial cells. In§contrast, a high-level of PP1g1 expression was§observed in interstitial cells, while much weaker§expression was observed in all stages of§spermatogenesis. Another PP1 isoform, PP1g was§predominant in spermatogonia, pachytene§spermatocytes, and interstitial cells. Examining the§temporal expression of PP1 enzymes in testes,§revealed a striking postnatal increase in PP1g2§levels compared to other isoforms. Testicular sperm§tails from Ppp1cc-null mice showed malformed§mitochondrial sheaths, extra outer dense fibers and§fibrous sheath in both the middle and principal§pieces. These data suggest that, in addition to its§previously documented role in motility, PP1g2 is§involved in sperm tail morphogenesis.
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