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The renin-angiotensin system and the mechanisms regulating this system developed during the adaptive evolution of vertebrates, along with many other systems involved in the integrated survival of the organism. §In this book, advances in research on the renin-angiotensin system are described with emphasis on the comparative aspects. Only this comparative approach provides the understanding of the structure and function of adaptive systems and facilitates the development of general principles governing these systems among the various animal groups.