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Removing Parathyroid Hormone by Immunoadsorption at Kidney Dialysis

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Carte Removing Parathyroid Hormone by Immunoadsorption  at Kidney Dialysis Shu Xia
Codul Libristo: 06824586
Editura VDM Verlag Dr. Müller, noiembrie 2008
The restoration of normal parathyroid hormone (PTH) §levels for kidney failure patients has to date... Descrierea completă
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The restoration of normal parathyroid hormone (PTH) §levels for kidney failure patients has to date §proven to be a very challenging clinical problem. §Middle molecular weight toxins such as PTH are §poorly dialyzed, and drug therapies require weeks to §months to lower serum PTH levels. Based on the §characteristic of high specific affinity between §antigen and antibody, a chromatographic column with §packing coated by monoclonal antibody placed in §series with a conventional hemodialyzer has been §designed to reduce PTH levels to normal within one §dialysis session. A mathematical model of the §modified dialysis circuit of the form of a single §delay differential equation, whose approximately §analytical solution was obtained emoplying a Padé §approximation, was developed which reproduces an in §vitro experiment with high accuracy, and indicates §that the immunosorptive column will be efficacious §in lowering PTH levels when scaled up to clinical §scenarios. Process intensification of the modified §dialyzer circuit was also investigated by §functionalizing the lumenal surfaces of the dialyzer §cartridge itself.

Informații despre carte

Titlu complet Removing Parathyroid Hormone by Immunoadsorption at Kidney Dialysis
Autor Shu Xia
Limba engleză
Legare Carte - Carte broșată
Data publicării 2009
Număr pagini 132
EAN 9783639161588
Codul Libristo 06824586
Greutatea 192
Dimensiuni 150 x 220 x 7
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