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The research group of the Japanese Circulation Society presents its most recent findings in this book for the international scientific community. They have gained new insights into the pathophysiologic mechanisms of the failing heart which will affect the diagnosis, evaluation and treatment of heart failure syndrome. Specifically, the book covers research into cellular biology, the conceptual framework of the mechanics of contraction and relaxation of the ventricle, myocardial energetics, neurohumoral adjustments, receptor pharmacology, and assist circulation systems of the heart.