Organic Chemistry of Enzyme-Catalyzed Reactions, Revised Edition

"The Organic Chemistry of Enzyme-Catalyzed Reactions" is not a book on enzymes, but rather a book on the general mechanisms involved in chemical reactions involving enzymes. An enzyme is a protein molecule in a plant or animal that causes specific reactions without itself being permanently altered or destroyed. This is a revised edition of a very successful book, which appeals to both academic and industrial markets. This book: illustrates the organic mechanism associated with each enzyme-catalyzed reaction; makes the connection between organic reaction mechanisms and enzyme mechanisms; and, compiles the latest information about molecular mechanisms of enzyme reactions. Accompanied by clearly drawn structures, schemes, and figures, it includes an extensive bibliography on enzyme mechanisms covering the last 30 years, explains how enzymes can accelerate the rates of chemical reactions with high specificity, provides approaches to the design of inhibitors of enzyme-catalyzed reactions, categorizes the cofactors that are appropriate for catalyzing different classes of reactions, shows how chemical enzyme models are used for mechanistic studies, describes catalytic antibody design and mechanism and includes problem sets and solutions for each chapter. It is written in an informal and didactic style.