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This book contains new methods, spectrophotometric and fluorometric were used for the accuracy, precision and sensitive for the determination of Ranitidine hydrochloride Drug in different samples and in pharmaceutical preparations, also formation anew complex Ranitidine - metal ions in acetonitrial solvent, and sandwich complex high colored intensity Ranitidne - metal ions - bypyridyl as anew form there complexes were identified by FT-IR spectrophotometric methods.