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Microdevices for pharmaceutical nanoparticle precipitation, downstream processing, and analysis
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The use of microfluidic systems for chemical and pharmaceutical production processes has been investigated for some time, as they can offer unique advantages through increased process control and extremely fast process steps. One example that can benefit from the use of microfluidic systems is the precipitation of lipid nanoparticles. Such particles are used as carriers for active ingredients that are difficult to dissolve in water or whose release needs to be controlled.In order to produce pharmaceutical carrier particles and to bring them into an applicable form, several process steps are required. The aim of this work was to demonstrate the closed chain of synthesis, purification, and analysis of lipid nanoparticles in pharmaceutical quality in a microfluidic system. For this purpose, several microfluidic devices were developed and combined.
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