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This volume brings together scientists and clinicians from diverse disciplines for discussions of oxidative injury in the nervous system. Areas of examination include: a review of metals and their role in oxidative injury, with special attention paid to iron the mechanisms by which the brain protects itself from oxidative harm the clinical diseases in which oxidative injury is known to contribute to the pathogenic process antioxidant therapeutic strategies in neurological disorders, and a proposed common pathway for oxidative injury in the brain.