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This book will be helpful principally to post-graduate and research scholar at the beginning of their research carrier. This includes general information, method of synthesis, reaction and biological activity of indole derivatives. The medicinal activity of indole was described along with brief literature and active compound of particular biological activities such as antimicrobial, anticancer, anti-inflammatory and analgesic, anticonvulsant etc. The brief literature of biological activities helpful to the research scholars for the selection of their projects along with biological activities.