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In this book, Goldschmidt inquires into the types of hereditary differences that produce new species. Goldschmidt used a wide range of research to formulate his own picture of evolution. Contrary to near-unanimity among scientists, he insisted that the neo-Darwinian theory of micromutations applied only within species and was no longer tenable as a general theory of evolution. Instead, Goldschmidt claimed, macroevolution resulted from larger jumps in genotype - across "bridgeless gaps" - related either to systemic mutations or to mutations affecting early development.