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This volume is the proceedings of the William Harvey Research Conference held in London on the 12th and 13th June 1997. It covers the biosynthesis of leukotrienes, their release in pathological conditions, progress in the characterisation of leukotriene receptors, and the elucidation of signal transduction mechanisms following receptor activation. Particular attention has been directed at the use of the increasing number of available leukotriene receptor antagonists and biosynthesis inhibitors in diseases such as asthma and rhinitis.