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This book constitutes the thoroughly refereed proceedings of the First International Conference on InformationTechnology in Bio- and Medical Informatics, held in Bilbao, Spain, in September 2010.§The 14 selected long papers and 8 selected short papers are divided in the following groups:Workflow management and database; Decision support and data management in biomedicine; Medical data modelling and information retrieval; Data mining in bioinformatics; Knowledge representation and data management in bioinformatics; Biological data and signal processing.