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This book inquires into the nature of scientific discovery. The focus is on six personalities and six scientific fields: Johannes Kepler and modeling, Buckminster Fuller and molecules, Linus Pauling and helices of biological systems, A. Kitaiigorodskii and packing of shapes, D.J. Bernal and quasicrystals, and Pierre Curie and symmetry breaking. Excerpts from conversations with 40 leading scientists, including 17 Nobel laureates, enliven the discussion. Culture and science blend inseparably in this book and natural curiosity is the only prerequisite to enjoy it. The award winning authors created this book for the interested general public and it is illustrated by striking images.