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The book aims to elucidate how genomics research progresses applied in heart diseases. It describes the developments of genome-scale technologies and their applications to all areas of cardiac investigations, such as genomics, functional genomics, epigenomics, etc., and how they relate to series of important breakthroughs in various heart diseases. Applying unbiased genomics combined with disease-focused and hypothesis-driven approach is one way to push forward our understanding of cardiac diseases. The book will be an important reference of introducing genomics in heart for scientists and graduate students who work on genomics and cardiology as well as for clinical physicians.