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This volume summarizes the Fourth Meadowbrook Symposium held in October 1988. Exciting new findings are discussed in the following areas: The synthesis of a nucleotide sequence that binds a specific steroid receptor and acts as controlling element for gene expression; the control of gene transcription by the interaction between transacting factors and DNA recognition sequences; the membership of the transacting factors in a large gene family that includes also steroid hormone receptors, transcription factors, protooncogenes, and homeobox proteins. Other topics are receptor down regulation and quantitive relationships between receptor binding and biological response.