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Customized Contact Lens Treatments for in-the-Eye Medication
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Hydrophilic polymer (polymacon, alphafilcon-A) and§silicone-based (balafilcon-A) hydrogel contact§lenses, before and after surface modification by§radio-frequency glow-discharge treatment (RFGDT),§were used to monitor methylene blue/silver nitrate§drug-surrogate uptake and elution. Infrared§spectroscopy revealed modified absorption peaks,§accordingly. Energy-dispersive x-ray (EDX) analysis§and inductively coupled argon plasma atomic emission§spectroscopy (ICP) confirmed silver lens depot§concentrations and were employed to measured eluate§concentrations, while visible spectrophotometry and§ICP spectrometry monitored methylene blue and silver§elution rates in static versus simulated eye-blinking§conditions. The conclusions reached are that (1)§initial drug uptake of surface modified lenses§increased in this order: polymacon alphafilcon-A §balafilcon-A lenses; (2) drug release rates of the§polymacon, and alphafilcon-A remained unaffected by§the RFGDT; (3) increased release rates occurred from§the RFGDT-surface-modified balafilcon-A lenses; and§(4) dynamic forces increased the release rates for§all contact lenses.
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