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This book covers the whole spectrum of drug design methods. The emphasis is on practical aspects and the usefulness and limitations of CADD in industrial research addressing topics such as: How to integrate CADD in the overall research process to give the best impact? What contributions can result? Where are the pitfals? What are the factors favouring/prohibiting successful CADD contributions? Are we doing the right things in the overall quest for a new drug? How to judge the usefulness/effectiveness of CADD? What are the principal needs and expected developments of CADD methods in the near future? An international group of experts practicing CADD methods in industry presents their broad experience. In this way the book may help to facilitate the development of new and better drugs.