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This monograph reports recent advances of inversion theory and recent developments with practical applications in frontiers of sciences, especially inverse design and novel computational methods for inverse problems. Readers who do research in applied mathematics, engineering, geophysics, biomedicine, image processing, remote sensing, and environmental sciencewill benefit from the contents since the book incorporates a background of using statistical and non-statistical methods, e.g., regularization and optimization techniques for solving practical inverse problems.