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This book constitutes the thoroughly refereed post-conference proceedings of the 11th International Meeting on Computational Intelligence Methods for Bioinformatics and Biostatistics, CIBB 2014, held in Cambridge, UK, in June 2014.§The 25 revised full papers presented were carefully reviewed and selected from 44 submissions. The papers focus problems concerning computational techniques in bioinformatics, systems biology, medical informatics and biostatistics.§