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This is the first comprehensive monograph on the comparative physiology of the pancreatic islets. Topics covered include: the evolution of the endocrine pancreas, the phylogenetic appearance of the islet hormones in invertebrates; the occurrence of the islet hormones in vertebrate organs other than the pancreas; the nervous and humoral regulations of the islet function; the functional strategies pancreatic islets apply to affect their various target organs; the phylogeny of molecular structure and function of the four major islets hormones (insulin, glucagon, pancreatic polypeptide, somatostatin); the current state-of-the-art, and important issues for future research. This book is an indispensable resource for investigators in a wide variety of research areas related to the islet organ, diabetes mellitus and gut physiology.