Colon Cancer Prevention

This volume covers recent research on all aspects of colon cancer prevention, including normal and abnormal colonic development, chemoprevention of colon cancer, the role of dietary factors in prevention, experimental approaches and mechanisms in prevention, as well as whether cell proliferation and apoptosis is the link between relative risk and prevention. Topics include: transcriptional regulation in intestinal development; colonic cell proliferation, differentiation and apoptosis; defects in the regulation of beta-catenin in colorectal cancer; dietary lipids, inflammation, and colon cancer; sulindac sulfone-induced regression of rectal polyps in patients with familial adenomatous polyposis; prevention of colon cancer and modulation of aberrant crypt foci; cell proliferation and apoptosis by retinoids and NSAIDs; mechanisms by which energy restriction inhibits carcinogenesis; dietary intervention studies of colorectal cancer; the genetics of hereditary non-polyposis colorectal cancer and non-polypotic colon cancer; familial association; colonic cell proliferation and apoptosis in rodent species; and nonsteroidal anti-inflammatory drugs (NSAIDs), cyclooxygenase and the cell cycle and their interactions in cancer.