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This book§constitutes revised selected papers from the 4th International Workshop on§Clinical Image-Based Procedures, CLIP 2015, held in conjunction with MICCAI§2015 in Munich, Germany in October 2015. The 15 papers presented in this§volume were carefully reviewed and selected from 22 submissions.§§CLIP§focuses on translational research. Therefore, the goal of the works presented§in this workshop is to bring basic research methods closer to the clinical§practice. A highlight of this workshop is the subject of strategies for§personalized medicine to enhance diagnosis, treatment and interventions.§