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Cell Polarity in Development and Disease
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Cell Polarity in Development and Disease offers insights into the basic molecular mechanisms of common diseases that arise as a result of a loss of ordered organization and intrinsic polarity. Included are diseases affecting highly polarized epithelial tissues in the lung and kidney, as well as loss and gain of cell polarity in the onset and progression of cancer. Although many of the molecular/genetic signalling pathways underlying many disorders are well studied biochemically, how the relevant cellular organization integrates with various signalling molecules is often less clear. This book addresses these ideas, providing a basic resource for understanding the biology of polarity and offering a starting point for those thinking of targeting cell polarity for translational medical research. Provides basic science understanding of cell polarity disease and developmentCovers diseases affecting polarized epithelial tissues in the lung and kidney, and in the progression of cancerIncludes historical context of cell polarity research for potential future breakthroughs
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