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In this riveting account of medical sleuthing, Dr. Jonathan A. Edlow tells the history of the discovery of Lyme disease over centuries and continents. He also provides the latest information about the disease and its treatment, explaining the recent widespread outbreaks and examining the controversies that have swirled over the diagnosis, vaccine, treatment, and even definition of Lyme disease. In a new preface, Dr. Edlow updates recent developments and controversies in Lyme disease research, discusses reactions from the two "camps" of the Lyme disease community, and writes about some of the reactions of patients to the book.