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BIOCOMP is an international conference that serves researchers, scholars, professionals, students, and academicians who are looking to both foster working relationships and gain access to the latest research results. The 2014 Congress was composed of research presentations, keynote lectures, invited presentations, tutorials, panel discussions, and poster presentations. Selected Topics: Gene Expression and Representation, Microarray, Sequencing, Alignment, and Related Bioinformatics Issues, Computational Biology and Medical Applications + Health Informatics and Related Issues, Protein and Structure Prediction, Folding, and Computational Structural Biology + Drug Design, Machine Learning, Data and Information Mining + Signal Processing and Data Quality Enhancement + Databases, Bioinformatics and Computational Biology.