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Derris scandens and premna tomentosa both plants are very important in inian medicinal area. I choose these plants due to their capability of pharma area. Moreover, previous reports showing good impression to follow the work. In this sequence we did lot of work also isolated and structure elucidated lot secandory metabolites such as Flavonoids, terpinoids, isoflavones and poly phenolic compounds. The above isolated compounds showed very good biological activity.