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Since the discovery some 15 years ago of benzodiazepine§modulatory sites associated with GABA A receptors, great§effort has gone into understanding their molecular§pharmacology and into developing new anxiolytic drugs that§interact selectively with them. Prominent in this research§has beenthe discovery that ~-carbolines, a different§chemical class from benzodiazepines, also act at these§receptors but that their effects are sometimes quite§different from those of the benzodiazepines.This book§documents the latest discoveries in the molecular§biology of the GABA A receptor and reveals how§an integration of the results of research inmolecular§biology, synthetic chemistry, biochemical and behavioral§pharmacology, and clinical pharmacology has paved the way§forthe development of ~-carbolines from substances inducing§anxiety and convulsions to a novel therapy for anxiety§states, achieving a behavioral selectivity through selective§actions at subtypes of receptors.
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