Analgesic,Antipyretic, Anti-arthritic activity of T.Procumbens leaves

To evaluate the Analgesic, Antipyretic and Antiarthritic activities of leaves extract of Tridax procumbens Linn. (Ethanolic and ethyl acetate) Analgesic activity was investigated against Acetic acid and sodium chloride induced Writhing test in rats. TPEE at 300mg/kg (P.O.) shows better analgesic activity than TPEAE. Ethanolic and Ethyl acetate extracts of Tridax procumbens were evaluated for antipyretic activity using hyperpyrexia induced in rabbits by Typhoid-Paratyphoid A, B vaccine. Like Paracetamol 100 mg/kg (I.V.) Tridax procumbens showed significant reduction in elevated body temperature at 300 mg/kg (P.O.) while Antiarthritic activity of Tridax procumbens leaves extract in complete Freud s adjuvant induced arthritis in rats. Antiarthritic activity was assessed based on the Physiological parameters, Haematological parameters and Knee joint Histopathology. The changes in the above said parameters were reversed by the Tridax procumbens leaves extract administered at the dose of 300 mg/kg orally. Hence further detailed investigation is required to isolate the compound responsible for the evaluated activities.