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This work was carried out to investigate the allelopathic effect of purslane, oats, nutsedge, alfalfa, sunflower, onion, and garlic against some summer (maize, grain sorghum, broom corn, sunflower, soybean, alfalfa, jew's mallow) and winter (wheat, faba bean, garlic, onion) crops on seedling growth parameters by leachate, decayed plants, previous plantations and root exudates. In addition trials were done to isolate the bioactive chemical constituents of some allelopathic plants (purslane, alfalfa and sunflower).