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In this issue of Clinics in Chest Medicine, guest editors Drs. Charles Dela Cruz and Guang-Shing Cheng bring their considerable expertise to the topic of COVID-19 Lung Disease: Lessons Learned. COVID-19 can cause lung complications ranging from pneumonia to acute respiratory distress syndrome and sepsis, resulting in lasting harm to the lungs and other organs. In this issue, top experts cover a wide variety of all-new, pandemic-related topics in the field, including both U.S. and global perspectives on lessons learned from COVID-19.