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Volume 81 of "Advances in Immunology" contains articles on a vast range of immunology topics including the regulation of the immune response by the interaction of chemokines and proteases as well as roles of the Semaphorin Family in immune regulation. It has a chapter devoted to B Lymphoid Neoplasms of Mice and another on the Zebrafish as a model organism to study development of the immune system. This volume will be of interest to immunologists in all industries. Edited by a new editor, Frederick W. Alt, it covers molecular mechanisms of host-pathogen interaction and discusses prions and the immune system.